A pane of glass fell from the Four Seasons Hotel Toronto and shattered on the ground below on Thursday afternoon.
Toronto Fire Services said the glass fell from the 19th floor of the hotel at Bay Street and Yorkville Avenue.
No one was injured, but a witness said the glass narrowly missed people in the area.
Engineers have been called in to repair the window.
Glass has fallen four other times from the same hotel since August 2013, including last May.
Yorkville Avenue is closed from Bay to Yonge.