Two people were taken to hospital for smoke inhalation, including a firefighter, after a two-alarm blaze in Parkdale early Saturday morning.
Fire crews were called to the home on Temple Avenue, near King and Dufferin streets, just after 2 a.m.
A firefighter and resident were taken to hospital and are expected to be fine.
Officials say the basement of the house was destroyed. No adjoining buildings were damaged.
Six people living in the home have been displaced and Red Cross has been notified.
There is no word yet what caused the fire.